Engineering the Morphostructural Properties and Drug Loading Degree of Organic–Inorganic Fluorouracil–MgAl LDH Nanohybrids by Rational Control of Hydrothermal Treatment

Layered double hydroxides (LDHs) or hydrotalcite-like compounds have attracted great attention for the delivery of anticancer drugs due to their 2D structure, exhibiting a high surface-to-volume ratio and chemical versatility. The drug is protected between layers from which it slowly released, thus increasing therapeutic effect minimizing side effects associated nonspecific targeting. This work aimed design LDHs with Mg Al (molar 2/1) in brucite-like layers, retained fluorouracil (5-FU; 5-FU/Al = 1, molar ratio) interlayer gallery as grow during co-precipitation step synthesis. To rationally control physicochemical properties, particularly size crystallites, aging following was performed under carefully controlled conditions by changing time temperature (i.e., 25 °C 16 h, 100 120 24 h). results revealed achievement crystals, are gathered three different agglomeration systems, tight loose, well loading degree final organic–inorganic hybrid nanomaterials. role played factors parameters affecting drug-controlled release highlighted assessing behavior 5-FU pH, solid mass/volume ratio, ionic strength. showed pH-dependent but not necessarily direct proportionality. After certain limit, mass diminishes rate release, whereas strength essential payload discharge.